Determination and Significance of Serum Vascular Endothelial Growth Factor and Estradiol and Urinary Basic Fibroblast Growth Factor in Infantile Hemangioma
Abstract：Objective To differentiate hemangiomas from vascular malformations and to provide the basis for the clinical stages of infantile hemangiomas by investigating the changes in serum levels of vascular endothelial growth factor(VEGF) and estradiol(E2) and urinary levels of basic fibroblast growth factor(bFGF).Methods A total of 138 cases of infantile hemangiomas and vascular malformations,selected in the among including 60 cases of proliferative hemangiomas(proliferative hemangiomas groups),38 cases of involuting hemangiomas(involuting hemangiomas groups) and 40 cases of vascular malformations(vascular malformations group).Serum VEGF and urinary bFGF levels were determined by ELISA and serum E2 levels were measured by electrochemiluminescence assay with automatic immune analyzer(Germany Roche Diagnostics GmbH) and compared with normal control group.Results Compared with proliferative hemangioma group,the levels of serum VEGF and E2 and urinary bFGF significantly decreased in involuting hemangioma group,vascular malformation group and normal control group(all P<0.01).Compared with involuting hemangioma group,serum E2 levels obviously decreased in vascular malformation group and normal control group(P<0.05).The levels of serum VEGF and urinary bFGF in control group were not significantly different from those in involuting hemangioma group and vascular malformation group(all P>0.05).The levels of serum VEGF and E2 and urinary bFGF in female infants were higher than those in male infants,but the differences were not significant(all P>0.05).Conclusion ELISA analysis of serum VEGF and urine bFGF levels and electrochemiluminescence assay for serum E2 detection are simple,easy and reliable in differentiating hemangiomas from vascular malformations and provide the basis for the clinical stages of infantile hemangiomas.
2012, Vol. 52 
